...and need to get out of my newsreader.
Filedropper. Share files of up to 5 GB size for free.
How to burn multiple CDs at the same time with ITunes. (Of course you need multiple burners...)
Eye-Fi wireless memory card. How'd you like to have your pictures sent wirelessly to your computer as you take them. This would be great at house parties.
FuseCal. Online app to sync ICal based calendars. Perfect for finding time to work out with over-scheduled profs. on vacation.
Fontstruct. Create your own fonts.
Most of the above links go to the sites on which I found these neat things. I was to lazy to make a bunch of 'via X' links.